Antiarrhythmic Action of Ambonestyl

Antiarrhythmic action of ambonestyl.

PRELIMINARY STUDIES " suggested that the capacity of a drug to suppress ventricular arrhythmia might be inherent in a chemical structure which does not possess certain actions previously associated with antiarrhythmic activity, e.g., elevation of electric threshold, depression of conduction, and local anesthesia. Ambonestyl, 2-diethylaminoethyl-isonicotinamide,* (MC 4112), was found to be a com...

Mechanisms of action of antiarrhythmic drugs.

Antiarrhythmic and arrhythmogenic action of inosine in experimental ventricular tachyarrhythmias.

OBJECTIVE To study the possible action of inosine on experimental ventricular tachyarrhythmias. MATERIAL AND METHODS We used 92 mongrel dogs weighing 13 kg-17 kg, anesthetized with 30 mg/kg sodium pentobarbital applied intravenously. Myocardial lesions were induced by injecting 1 ml-1.5 ml of 70% phenol in the free wall of the left ventricle. In 36 dogs, the ventricular arrhythmia (VT) was in...

Antiarrhythmic drug action. Blockade of the inward sodium current.

THE mechanisms of action of antiarrhythmic drugs were discussed in these reviews over a decade ago (Rosen and Hoffman, 1973). Since then, important new concepts of the blocking action of drugs have been proposed and tested experimentally. Several attempts at a quantitative voltage clamp analysis of the blocking action of antiarrhythmic drugs have been made. The mechanism of the blocking action ...

Antiarrhythmic profile and endothelial action of novel decahydroquinoline derivatives.

We tested antiarrhythmic and endothelial action of novel decahydroquinoline derivatives. Antiarrhythmic activity was analyzed using models of aconitine-, calcium chloride-, and adrenaline-induced arrhythmias in rats. Potency to induce nitric oxide (NO)-dependent coronary vasodilation was assessed in isolated guinea pig heart perfused according to Langendorff technique. Among 15 novel decahydroq...